{"id":7930,"date":"2021-08-24T11:54:57","date_gmt":"2021-08-24T11:54:57","guid":{"rendered":"https:\/\/hyperbaricmontreal.com\/lallergie-et-limmunologie\/"},"modified":"2023-04-18T14:28:14","modified_gmt":"2023-04-18T14:28:14","slug":"lallergie-et-limmunologie","status":"publish","type":"page","link":"https:\/\/hyperbaricmontreal.com\/fr\/lallergie-et-limmunologie\/","title":{"rendered":"L’ALLERGIE ET L’IMMUNOLOGIE"},"content":{"rendered":"

L’ALLERGIE ET L’IMMUNOLOGIE<\/strong><\/h1><\/h2><\/div>

L’ALLERGIE ET L’IMMUNOLOGIE<\/strong><\/h2><\/h2><\/div>
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Plusieurs recherches et \u00e9tudes examinent l’influence de l’exposition \u00e0 l’oxyg\u00e8ne hyperbare (HBO2) et de la d\u00e9compression sur diverses facettes de la r\u00e9ponse immunitaire. Les changements potentiels au cours de l’exposition comprennent une diminution du rapport CD4+ CD8+, une diminution de la prolif\u00e9ration des lymphocytes et une activation des neutrophiles qui migrent vers des r\u00e9gions o\u00f9 la pression d’oxyg\u00e8ne est \u00e9lev\u00e9e.<\/p>\n

Il peut \u00e9galement y avoir une activation de la cascade du compl\u00e9ment pendant la d\u00e9compression. Les indicateurs cliniques de la suppression immunitaire globale comprennent une diminution de la r\u00e9ponse aux antig\u00e8nes, un affaiblissement des r\u00e9ponses auto-immunes et un rejet plus lent des allogreffes.<\/p>\n

Source : Brenner I, Shephard RJ, Shek PN. Fonction immunitaire en milieu hyperbare <\/a>, en plong\u00e9e et en d\u00e9compression. Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. 1999 ;26(1):27-39. https:\/\/europepmc.org\/article\/med\/10353182<\/p>\n<\/div>

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Les tensions d’oxyg\u00e8ne jouent un r\u00f4le important dans l’issue des infections. L’oxyg\u00e8ne est cidal ou statique pour les micro-organismes qui n’ont pas de d\u00e9fenses contre les oxydants. L’hyperoxie et l’oxyg\u00e8ne hyperbare exercent des effets antimicrobiens en augmentant le flux intracellulaire d’esp\u00e8ces r\u00e9actives de l’oxyg\u00e8ne. <\/span><\/p>\n

Chez les bact\u00e9ries, ces esp\u00e8ces provoquent des ruptures de brins d’ADN, la d\u00e9gradation de l’ARN, l’inhibition de la biosynth\u00e8se des acides amin\u00e9s et l’inactivation des prot\u00e9ines de transport membranaire. Les tensions d’oxyg\u00e8ne affectent \u00e9galement l’activit\u00e9 des agents antimicrobiens. En g\u00e9n\u00e9ral, l’hyperoxie potentialise l’activit\u00e9 de nombreux m\u00e9dicaments antimicrobiens, tandis que l’ana\u00e9robiose la r\u00e9duit. <\/span><\/p>\n

En ce qui concerne les d\u00e9fenses de l’h\u00f4te, l’hyperoxie \u00e9l\u00e8ve la tension de l’oxyg\u00e8ne dans les tissus infect\u00e9s \u00e0 des niveaux qui facilitent la destruction par les leucocytes en fonction de l’oxyg\u00e8ne. L’hyperoxie prolong\u00e9e inhibe la synth\u00e8se de l’ADN dans les lymphocytes et nuit \u00e0 l’activit\u00e9 chimiotactique, \u00e0 l’adh\u00e9rence, \u00e0 la capacit\u00e9 phagocytaire et \u00e0 la g\u00e9n\u00e9ration de rafales oxydatives dans les leucocytes polymorphonucl\u00e9aires et les macrophages.<\/span><\/p>\n

Source : Matthew K. Park, Roy A. M. Myers, Louis Marzella, Oxygen Tensions and Infections : Modulation de la croissance microbienne, de l’activit\u00e9 des agents antimicrobiens et des r\u00e9ponses immunologiques, <\/span>
\n Clinical Infectious Diseases<\/span>
\n<\/i>Volume 14, num\u00e9ro 3, mars 1992, pages 720-740, <\/span>
\n https:\/\/doi.org\/10.1093\/clinids\/14.3.720<\/span>
\n<\/a><\/p>\n

Consultez la section ci-dessous pour obtenir des informations d\u00e9taill\u00e9es sur la recherche et les \u00e9tudes li\u00e9es \u00e0 votre sp\u00e9cialit\u00e9.<\/span><\/p>\n

RECHERCHE ET \u00c9TUDES<\/span><\/h3>\n

Justification physiologique et biochimique du traitement des patients atteints de COVID-19 par l’oxyg\u00e8ne hyperbare <\/span>
\n https:\/\/www.uhms.org\/images\/MiscDocs\/Physiologic_and_biochemical_rationale_for_treating_UHM_48-1.pdf<\/span>
\n<\/a><\/p>\n

Les effets de l’oxyg\u00e8ne hyperbare sur la polyarthrite rhumato\u00efde : Une \u00e9tude pilote <\/span>
\n https:\/\/pubmed.ncbi.nlm.nih.gov\/32947434\/<\/span>
\n<\/a><\/p>\n

HBO th\u00e9rapie en h\u00e9matologie et immunologie <\/span>
\n https:\/\/doi.org\/10.1007\/978-3-319-47140-2_26<\/span>
\n<\/a><\/p>\n

Tensions d’oxyg\u00e8ne et infections : Modulation de la croissance microbienne, de l’activit\u00e9 des agents antimicrobiens et des r\u00e9ponses immunologiques <\/span>
\n https:\/\/academic.oup.com\/cid\/article-abstract\/14\/3\/720\/282105<\/span>
\n<\/a><\/p>\n

Oxyg\u00e9nation hyperbare dans la th\u00e9rapie globale des patients atteints de polyarthrite rhumato\u00efde (\u00e9tude clinico-immunologique) <\/span>
\n https:\/\/europepmc.org\/article\/med\/1838726<\/span>
\n<\/a><\/p>\n

Oxyg\u00e8ne hyperbare dans la r\u00e9ponse inflammatoire syst\u00e9mique <\/span>
\n https:\/\/pubmed.ncbi.nlm.nih.gov\/15034647\/<\/span>
\n<\/a><\/p>\n

Effet du traitement par oxyg\u00e8ne hyperbare sur les param\u00e8tres immunologiques dans la scl\u00e9rose en plaques <\/span>
\n https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1600-0404.1989.tb03790.x<\/span>
\n<\/a><\/p>\n

Modification de la s\u00e9cr\u00e9tion in vivo et in vitro de TNF-\u03b1, IL-1 et IL-6 par les monocytes circulants pendant le traitement \u00e0 l’oxyg\u00e8ne hyperbare chez les patients atteints de la maladie de Crohn p\u00e9rianale <\/span>
\n https:\/\/link.springer.com\/article\/10.1023\/A:1027378532003<\/span>
\n<\/a><\/p>\n

L’oxyg\u00e8ne hyperbare inhibe la synth\u00e8se de cytokines pro-inflammatoires induite par un stimulus par les monocytes-macrophages d\u00e9riv\u00e9s du sang humain <\/span>
\n https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1046\/j.1365-2249.2003.02248.x<\/span>
\n<\/a><\/p>\n

Fonction immunitaire en milieu hyperbare, en plong\u00e9e et en d\u00e9compression. <\/span>https:\/\/europepmc.org\/article\/med\/10353182<\/span><\/a><\/p>\n

Immunosuppression par l’oxyg\u00e8ne hyperbare <\/span>
\n https:\/\/www.surgjournal.com\/article\/0039-6060(80)90060-4\/fulltext<\/span>
\n<\/a><\/p>\n

\u00c9volution de la carri\u00e8re de l’oxyg\u00e8ne hyperbare dans la septic\u00e9mie : De l’augmentation de l’apport en oxyg\u00e8ne \u00e0 la modulation de la r\u00e9ponse immunitaire <\/span>
\n https:\/\/journals.lww.com\/ccmjournal\/Citation\/2006\/10000\/Evolving_career_of_hyperbaric_oxygen_in_sepsis_.37.aspx<\/span>
\n<\/a><\/p>\n

L’oxyg\u00e9noth\u00e9rapie hyperbare att\u00e9nue les r\u00e9ponses pro-inflammatoires et immunitaires chez les souris knock-out pour l’apolipoprot\u00e9ine E <\/span>
\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2562533\/<\/span>
\n<\/a><\/p>\n

L’effet de l’oxyg\u00e8ne hyperbare sur l’immunit\u00e9 cellulaire et l’\u00e9tude de son m\u00e9canisme <\/span>
\n https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/0928468094900213<\/span>
\n<\/a><\/p>\n

Effet suppressif de l’oxyg\u00e9nation hyperbare sur les r\u00e9ponses immunitaires de souris normales et auto-immunes. <\/span>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1554111\/<\/span><\/a><\/p>\n

Application de l’oxyg\u00e8ne hyperbare \u00e0 la transplantation h\u00e9patique <\/span>
\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5223312\/<\/span>
\n<\/a><\/p>\n

Les effets anti-inflammatoires de l’oxyg\u00e9nation hyperbare au cours de la colite induite par le DSS chez les souris BALB\/c comprennent des changements dans l’expression g\u00e9n\u00e9tique de HIF-1\u03b1, des cytokines pro-inflammatoires et des enzymes antioxydantes <\/span>
\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5021505\/<\/span>
\n<\/a><\/p>\n

Suppression de la synth\u00e8se des anticorps humoraux lors de l’exposition \u00e0 l’oxyg\u00e9nation hyperbare <\/span>
\n https:\/\/pubmed.ncbi.nlm.nih.gov\/571294\/<\/span>
\n<\/a><\/p>\n

Impact de l’oxyg\u00e9noth\u00e9rapie hyperbare sur l’\u00e9volution clinique de la pancr\u00e9atite aigu\u00eb et du syndrome de r\u00e9ponse \u00e0 l’inflammation syst\u00e9mique <\/span>
\n https:\/\/pubmed.ncbi.nlm.nih.gov\/18819393\/<\/span>
\n<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

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Quels sont les avantages de l’OHB ?<\/p><\/h3><\/div>

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L’oxyg\u00e9noth\u00e9rapie hyperbare am\u00e9liore la qualit\u00e9 de vie du patient dans de nombreux domaines lorsque le traitement standard est inefficace.<\/span><\/p>\n<\/div>

EN SAVOIR PLUS<\/span><\/a><\/div><\/div><\/div>
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L’OHB peut-elle vous aider ?<\/p><\/h3><\/div>

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Oui. Il peut \u00eatre b\u00e9n\u00e9fique en cas de faibles niveaux d’oxyg\u00e8ne (hypoxie) et d’inflammation.<\/p>\n<\/div>

EN SAVOIR PLUS<\/span><\/a><\/div><\/div><\/div>
<\/span><\/a><\/span>

L’oxyg\u00e8ne de la vie<\/p><\/h3><\/div>

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L’oxyg\u00e8ne peut \u00eatre utilis\u00e9 \u00e0 des fins th\u00e9rapeutiques pour traiter un large \u00e9ventail d’affections dans lesquelles les tissus ont \u00e9t\u00e9 endommag\u00e9s par un manque d’oxyg\u00e8ne.<\/p>\n<\/div>

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